Artificial lipid membranes have become indispensable model systems for understanding the structural and functional properties of biological membranes. By replicating the essential features of natural lipid bilayers under controlled experimental conditions, these biomimetic platforms enable detailed investigations of membrane organization, transport processes, protein?lipid interactions, and cellular communication. This article provides an overview of the major classes of artificial lipid membrane systems, including black lipid membranes, solid-supported lipid bilayers, tethered bilayer lipid membranes, and synthetic vesicles, highlighting their structural characteristics, fabrication approaches, advantages, and limitations. It further discusses their diverse applications in membrane chemistry, including biosensor development, drug discovery and permeability testing, electrophysiological studies, and synthetic biology. Recent advances in artificial cell research and membrane engineering demonstrate the growing potential of these systems for developing responsive biomimetic platforms capable of mimicking complex cellular functions. Although challenges remain in recreating the dynamic complexity of living cell membranes, continued progress in membrane engineering, nanotechnology, and synthetic biology is expected to expand the practical applications of artificial lipid membranes in biomedical research, diagnostics, personalized medicine, environmental monitoring, and sustainable biotechnology. As increasingly sophisticated model systems emerge, artificial lipid membranes will continue to serve as powerful tools for advancing both fundamental membrane science and innovative technological applications.