White Spot Syndrome Virus (WSSV) is one of the most serious viral diseases affecting shrimp aquaculture, causing rapid mortality and major economic losses worldwide. Several vaccination strategies have been explored to control this pathogen, including subunit vaccines, inactivated whole-virus vaccines, DNA vaccines, antibody-based approaches, and RNA interference. Among these, VP28-based recombinant vaccines and DNA vaccines have shown promising protective effects under experimental conditions. However, challenges related to delivery methods, scalability, and field-level performance still limit their commercial application.