Zoonotic diseases are infections that can be transmitted between animals and humans. These diseases pose a major threat to public health, livestock productivity, and the livelihoods of farmers worldwide. Individuals who work closely with animals, such as farmers, veterinarians, and livestock handlers, are at a higher risk of exposure to zoonotic pathogens. Common zoonotic diseases associated with livestock include brucellosis, tuberculosis, leptospirosis, and rabies. These infections can spread through direct contact with infected animals, contaminated milk, animal products, or vectors such as ticks and mosquitoes. Awareness, early detection, and preventive measures play an important role in controlling the spread of zoonotic infections. Proper farm hygiene, vaccination of animals, use of protective equipment, and safe handling of milk and meat products can significantly reduce the risk of transmission. Strengthening collaboration between veterinary and human health sectors through the One Health approach is essential for effective disease management. Protecting both farmers and animals from zoonotic diseases is crucial for improving public health, ensuring food safety, and promoting sustainable livestock production.