Fish have exceptional skeletal flexibility and bone regeneration ability, allowing them to adapt to environmental changes and recover from traumas. Fish, unlike mammals, can continuously remodel and regenerate their skeletal structures. This article explores the structure of fish skeletons, skeletal plasticity mechanisms, and the cellular and molecular basis of bone regeneration, including the roles of osteoblasts and osteoclasts, as well as pathways such as Wnt and Bone morphogenetic protein (BMP). It also looks into the effects of genetic, dietary, and environmental factors on bone health. Comparative studies with mammals demonstrate fish's superior regenerating ability, which has implications for regenerative medicine and aquaculture. Understanding these mechanisms can help to enhance fish health in farming and conservation, as well as further biomedical research.