Cleome gynandra is a widely found plant that grows as a weed in barren lands and agricultural fields across India. Globally, it is utilized in various traditional medicine systems to treat numerous ailments and is also incorporated into different culinary practices due to its impressive nutritional and antioxidant benefits. In India, traditional healers commonly use it to manage conditions such as epilepsy, irritable bowel syndrome, and parasitic infections. The plant is rich in proteins, amino acids and minerals, making it a potentially valuable crop that can be easily cultivated for economic purposes. This review article highlights the medicinal uses of Cleome gynandra, citing its properties as an immunomodulator, antioxidant, anticancer agent, and analgesic. Given these established benefits, Cleome gynandra shows promise as a potential therapeutic option in the future.